Why does savella cause weight loss

Read the last paragraph of this blog to find out. Milnacipran was also associated with some weight loss in a rather overweight FM population over two years of treatment. Meanwhile a quite small study found no significant differences in pain reduction or cognitive improvement between milnacipran and placebo.

By the drug industry was clearly tiring of meta-analyses finding rather low clinical benefits to their drugs. A large study continued the push-back from the drug industry. Attempts to broaden the reach of milnacipran ensued. It proved to be helpful in reducing the frequency of migraine and headache , two common issues in FM, in a study. A meta-analysis, however, suggested Savella was no better than placebo at reducing neuropathic pain. Finally, the first pediatric study of milnacipran in FM had mixed results.

The trial — co-authored by Lucinda Bateman — suggested the drug may improve symptoms of FM in kids at about the same rate as it does in adults, but the authors had so much difficulty enrolling pediatric patients that the trial was halted early. People with FM have had mixed results on Savella. Lyrica, in particular, has a bad reputation for side effects — including the dreaded weight gain. For Savella nausea seems to be the biggest problem.

Data mining efforts like those listed in this study may clear up some of the mystery regarding which drugs work for who…. Realizing they have a PR problem, drug companies are trying to fine-tune who they are giving their drugs to. An analysis of three large trials revealed that one subset of FM patient benefited the most from Savella.

It found that FM patients with. On the other hand, if you can get your anxiety and sleep under control — you might. People with fibromyalgia trying Savella might want to do two things. Have you tried Savella? Tell us how it went here. I have high pain, high anxiety, very bad sleep problems, significant physical limitations. In , I was given Savella and it has helped a great deal until early July this year, when I had a two day stay in the hospital and had to have 2units of blood.

About days after I got out of the hospital, this terrible flare started and is not being helped by ANYthing…not even 30 mg of Oxycodone a day. My sister thinks this flare has something to do with the blood transfusion, since it was the only thing that was significantly different about my daily life. Who knows? Nausea is a common symptom of Savella.. I wonder if you should drop your dose a bit and then go back up? Jan: I agree with your sister, that the blood transfusion, in fact the whole trauma of hospitalization, what lead you to it and the blood transfusion is more than enough to put a person with FM into a flare.

I hope you are simply resting and sleeping as much as you can. Sometimes the pain is so bad that your bedding hurts. Same here. Ive tried everything possible to try to make my bed work comfortable for me no luck. Same with pillows. Ihave tried so many n nothing. I have tried every kind of mattress over the years — at great expense — but am now sleeping better, with less discomfort.

Have you been tested for Lyme? I seem to fit the profile of patients who may do well with Savela. I did awesome on it. It got me to a much better place in life over 5 years ago. I have been on Gabapentin for seven years. It has been pretty effective for my neurological pain. In the last year or so that is reducing and one of the side effects of Gabapentin is sleepiness. I read about Topiramate on this website and thought I would give it a try; but, now I am thinking I should try Savella as I do fit the right criteria.

Looking forward to what others have to say. I took Topamax…not sure if is the same exact drug you mention…but I suffered permanent kidney damage after about 6 years on it.

Went into Stage 4 renal disease. My best advise to you is to demand your doc monitor both your liver and renal function every 6 mos. Good luck and God bless. Topiramate is the generic name for Topamax. I was warned by my doctor that this medication prevents one from sweating adequately and therefore to be careful of becoming over-heated.

In fact, for a time, I was on both simultaneously, as they were prescribed by two different doctors for two different things. In my experience, if you take more than mg per day, you will experience severe muscle pain on it. You will also experience excessive sleepiness with it on individual doses of 75 mg or higher, depending on how it affects you personally.

Initially, I began to experience weight loss on as little as mg per day, but as I advanced through peri menopause and into menopause, I found that it took higher doses for that weight loss to occur and it was slower. I would never recommend exceeding mg per day. My doctor suddenly increased my dose from to mg per day in The result was awful. I had to back off the dose and my appetite, which was barely existent, suddenly became ravenous!

So make sure your dosage changes are very gradual, like mg no more often than months. I also found that it made me very irritable at higher doses. This is a drug that can seem very innocuous at lower doses and becomes disturbingly powerful at higher doses. The weight loss may seem an attractive side effect, but you can pay for it with negative side effects. Sadly, I found it impossible to control my weight during a few months I was off of it, which was part of the motivation for going back on it again.

Now I feel kind of trapped on it. These are things I learned from experience on Topiramate. Neither my doctor, pharmacist, nor anything I looked up online warned me about any of this.

Good luck. Bri, thanks for your input. I am the one who made the suggestion to my doctor as I find that after seven years the Gabapentin is not as effective as it used to be. I got the idea of the Topamax from the Health Rising website.

My daughter, who is now 13, took Topamax for 18 months between the ages of 11 and 12 for migraines which run in my family. She took 25mg twice a day and she did not have any side effects. She was taking the lowest dose possible and it was very effective. The article cites very low doses similar to what my daughter took and nowhere near the doses you mention. I am not diagnosed with FM and have never really considered myself as having FM but I do experience neurological pain.

Pins and needles and burning and pinching and biting. These are words I would use to describe my pain. Mainly in my extremities and the cap of my brain. Thank you for relaying your experience, especially the part about weight loss. I am very small, 95 lbs and this is a good weight for me.

At one time, at the beginning of my illness I was at 85 lbs for a couple of years. I am concerned but it seems that no matter what drug I consider switching to people talk of negative side effects. I have been sitting on the fence for over six months about what to do. Man this is hard. I also I damaged to my kidney from taking it.

I ended up getting kidney stones also. In the end I lost 1 of my kidneys. A warning. If you take an MAOI antidepressant, Savella might be dangerous as together they might cause serotonin toxicity, so perhaps come off the MAOI slowly, allow a washout of?

Also of interest is how these meds can cause weight loss. I know when I was taking the combination, I came down to my lowest weight ever and my friends said I looked unhealthy and gaunt just when I thought I was getting the super-model look. I read where another person wrote that they went from 95 to 85 lbs. It helps me sleep which is awesome, but I pay for it with worsening fatigue, dizziness, heavy limbs, brain fog. Does make me dopey, which helps me get to sleep if I need it at night.

Baclofen is a muscle relaxant for spastic conditions. I was on it for years until I stopped taking it recently. It never did anything for me. It never made me sleepy, it never relieved my pain even a little. It made no difference when I discontinued it. Cort I believe just had an article about low-dose trazadone, a tricyclic like nortriptyline formerly known as Elavil. Super low doses of trazadone had been found to help with our sleep cycle issues and not leave the person all fogged up in the am, any more than the usual I should say.

I started at 25mg but have been taking 50 for quite a few years. I hope it helps you, too! I find small doses of Savella restorative. It definitely helps me sleep through the night at 25mg and helps with pain and stiffness. However, at 25mg I drip sweat at the drop of a hat, so I try cutting back to I take 30mg of Cymbalta every other day for pain also.

Except for the phenomenal fatigue I have probably more due to cfs I can sometimes forget I have fibromyalgia and am grateful I am no longer in the kind of pain I once was.

Especially my head- my hair gets soaked! I googled it and it is a major problem with many. The extreme sweating has lessened dramatically as I continue to wean off the Cymbalta.. This medicine is passed on to breast milk. Before breastfeeding, consult your doctor. Interactions Using Savella with other drugs can make you sleepy and can make this effect worse. Ask your doctor before taking opioid medication, a sleeping pill, a muscle relaxer, or an anxiety or seizure medication.

Other medications might interact with milnacipran, including prescription and over-the-counter medicines, vitamins, and some herbal products. Tell your doctor about all your current medicines and any medicines you are taking. Overdose If someone has overdosed and has serious symptoms such as passing out or trouble breathing, seek medical advice. Do not take more. Missed Dose If you forget to take any of the doses, take it as soon as you remember. If it's time for the next dose, skip the missed dose.

Take the next pill. Storage Store this medicine far away from light, heat, and moisture and keep it at room temperature. Keep out of the bathroom. It should be kept away from kids. When this has expired or is no longer required, properly dispose of it. Savella vs Cymbalta Savella Cymbalta Savella treats fibromyalgia. Cymbalta Improves mood and relieves certain types of pain.

It is used to treat pain caused by a condition called fibromyalgia that affects muscles, tendons, ligaments, and tissue support. Initial treatment of fibromyalgia in adults. Accessed June 21, Hauser W, et al. Review of pharmacological therapies in fibromyalgia syndrome. See also Acupuncture Antidepressant withdrawal: Is there such a thing?

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You may find taking Savella more tolerable if you take it with a meal. Other common side effects are headache, constipation, dizziness, insomnia, hot flush, hyperhidrosis excessive sweating , vomiting, palpitations, increased heart rate, dry mouth, and hypertension. In clinical trials, Savella was not shown to be associated with weight gain or weight loss.

Patients in clinical trials who took Savella had an average weight loss of 1. This is not a complete list of side effects. Please see the Important Risk Information about Savella. And ask your healthcare provider about possible risks and side effects.

Print Page. SAVELLA is not used to treat depression, but it acts like medicines that are used to treat depression antidepressants and other psychiatric disorders.